The effect of pain relievers on brain activity and human emotion


Received: 15 Mar 2022
Revised: 21 Apr 2022
Accepted: 20 M2ay 2022

Neda Kaffash, Fardad Farokhi

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https://dx.doi.org/10.22034/JPSP.2022.23052204

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Abstract

Acetaminophen oral (APAP) and non-steroidal anti-inflammatory drug (NSAID) are powerful medicines used to reduce and relief the pain. These painkillers used for mild to moderate pain relief but studies show that these pain killers affect both physical pain and social pain. The finding of a new scientific research noted that APAP and NSAID affect cognitive and affective processes. In this survey, we represent the effect of APAP and NSAID on human emotion (happiness, sadness, neutral) and behavior by using EEG brain signals. After that, we indicate the brain over activity and brain locations with Quantitative electroencephalography. At least we have statistical analysis with SPSS. As a result, APAP have a greater effect on emotions than NSAID.

Keywords: APAP, NSAID, EEG signal, painkiller, emotion.


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References

[1] Anderson, B. J. (2008). Paracetamol (acetaminophen): Mechanisms of action. Pediatric Anesthesia, 18, 915–921.

[2] Rhudy, J. L., Williams, A. E., McCabe, K. M., Russell, J. L. & Maynard, L. J. 2008 Emotional control of nociceptive reactions (ECON): do affective valence and arousal play a role? Pain 136, 250–261. (doi:10.1016/j.pain. 2007.06.031).

[3] DeWall, C. N., Chester, D. S., & White, D. S. (2015). Can acetaminophen reduce the pain of decision-making? Journal of Experimental Social psychology, 56, 117–120.

[4] Price, D. D., Milling, L. S., Kirsch, I., Duff, A., Montgomery, G. H. & Nicholls, S. S. 1999 An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 83, 147–156. (doi:10.1016/S0304-3959(99)00081-0).

[5] Craig, A. D. (2009). How do you feel—now? The anterior insula and human awareness. Nature Reviews Neuroscience, 10,59–70.

[6] Graimann B, Pfurtscheller G, Allison B. Brain–computer interfaces: a gentle introduction. In: Graimann B, Pfurtscheller G, Allison B, editors. Brain–computer interfaces: revolutionizing human–computer interaction. London: Springer; 2010. p. 1–28

[7] Pini, L. A., Sandrini, M., & Vitale, G. (1996). The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. European Journal of Pharmacology, 308, 31–40.

[8] Way, B. M., & Taylor, S. E. (2010). Social influences on health: Is serotonin a critical mediator? Psychosomatic Medicine, 72, 107–11.doi:10.1097/PSY.0b013e3181ce6a7d

[9] Lindquist, K. A., & Barrett, L. F. (2012). A functional architecture of the human brain: Emerging insights from the science of emotion. Trends in Cognitive Sciences, 16, 533–540.

[10] Hassanzadeh Rad A, Chatrnour G, Ghazanfar Tehran S, Fakhre Yaseri A. The association between preeclampsia and COVID-19; a narrative review on recent findings. Journal of Renal Injury Prevention. 2022;11. (link)

[11]   Hassanzadeh Rad A, Fakhre Yaseri A. The association between COVID-19 and gestational diabetes mellitus: a narrative review. J Ren Endocrinol. 2022;8:e17062. (link)

[12]   Hassanzadeh Rad A, Fakhre Yaseri A. The therapeutic, preventive, and immune-boosting effects of some minerals and vitamins in COVID-19: A narrative review. Journal of Parathyroid Disease. 2022;10:e9151. (link)

[13] Vaping Products And Asthma In Youths: A Review Of The Prospective Study, S Khosravaniardakani, International Journal of Medical Investigation 11 (1), 2022 (link)

[14] Obesity accelerates leukocyte telomere length shortening in apparently healthy adults: a meta-analysis, S Khosravaniardakani, DO Bokov, T Mahmudiono, SS Hashemi, N Nikrad, Frontiers in nutrition 9, 2022 (link)

[15] Epidemiological and Pathological Characteristics of Renal Cell Carcinoma with Outcome Evaluation: A Single Center Study from Shiraz, Iran, S Khosravaniardakani, MH Anbardar, S Khodamoradi, S Peyravi, International Journal of Medical Investigation 11 (2) (link)

[16] Genotoxicity of Noscapine Nanosuspension Prepared by Microfluidic Reactors on HepG2 Cell Line, M Azarian, A Amani, MA Faramarzi, A Eidi, A Divsalar, Iranian Journal of Chemistry and Chemical Engineering (IJCCE) 39 (5), 145-155, 2020 (link)

[17] Genotoxicity of noscapine nanosuspension on DU145 human prostate cancer (spheroid cell model), SK Malayer, H Ghourchian, M Azarian, Adv Cell Sci Mut. 2019; 2 (1): 1-7 Adv Cell Sci Mut. 2019, Volume 3, Issue 1 (link)

[18] The implication of calcium score and pentraxin-3 in non-invasive identification of significant coronary artery stenosis in chronic stable angina pectoris, H Haybar, M Davoodi, A Shahlaee, AES Babaki, Z Fazelinezhad, World Journal of Cardiovascular Diseases 3 (07), 433

[19] Financial hardship and mental health conditions in people with underlying health conditions during the COVID-19 pandemic in Bangladesh, MSH Sujan, R Tasnim, MS Islam, MZ Ferdous, A Haghighathoseini, Heliyon 8 (9), e10499, 2022 (link)

[20] Self-medication practices and associated factors among COVID-19 recovered patients to prevent future infections: A web-based survey in Bangladesh, MSH Sujan, A Haghighathoseini, R Tasnim, MS Islam, SM Salauddin, Asian Journal of Health Sciences, http://ajhs.biomedpress.org/index.php/aj, 2022 (link)

[21] Prevalence and determinants of mental well-being and satisfaction with life among university students amidst COVID-19 pandemic, MSH Sujan, AH Haghighathoseini, R Tasnim, RK Ripon, SA Ripon, Journal of Psychological Research, 2022 (link)

 

 


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